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- Accelerated healing of post-operative surgical wounds (partial thickness wounds and second degree burns; double blind, control, in vivo animal study p>.001)3
- Wounds treated with Periogenix demonstrated an up-regulation of VEGF4, collagens I and III, and matrix metalloproteinase levels
- Collagen production12,13,14
- Phagocytosis (engulfing of microorganisms, cells, or debris by macrophages or neutrophils)16
- Neutrophil-mediated oxidative microbial killing17
- Degradation of necrotic wound tissue18
- Included universal-fit disposable dental trays ensure comfortable consistent application
- High concentration of oxygen produces significant emulsion expansion, ensuring good contact with the treatment area
- Neutral taste and smooth texture
- 30 ML (1 oz) Canister of Emulsion
- 30 Disposable Dental Trays
* Epithelization was used as indicator of healing. Epithelization considered complete (healed) if no defect(s) were present; any defect(s) in the wound area indicated that healing was incomplete.
1. Accelerated Wound Healing in Animals; Davis SC, Cazzaniga AL, et al. Topical oxygen emulsion. Arch Dermatol. Oct 2007; 143(10):1256.
2. Clinical data on file.
3. Partial thickness wounds evaluated starting day 3 (p <0.001, days 4-7). 2nd degree burns evaluated starting day 7 (p <0.001, days 7-11, P<.01 day 12).
4. Vascular endothelial growth factor (VEGF).
5. Perfluorodecalin phase of Periogenix dissolves approx. 16x more O 2 and 3x more CO 2 than water (49 ml O 2 /100 ml and roughly 140 ml CO 2 /100 ml). Chemtech Volume 29, No. 10,7-12. (Table 1: Physical properties of water and some fluorocarbon liquids).
6. Data on file.
7. M. Stucker et. al. The cutaneous uptake of atmospheric oxygen contributes significantly to the oxygen supply of human dermis and epidermis. Journal of Physiology (2002), 538.3, pp. 985-994.
8. LaVan FB, Hunt TK, Oxygen and wound healing. Clin Plast Surg. 1990;17(3):463-470.
9. Niinlkoski J, Hunt TK, Dunphy JE. Oxygen supply in healing tissue. Am J Surg. 1972;123(3):247-252.
10. Meltzer T, Myers B. The effect of hyperbaric oxygen on the bursting strength and the rate of vascularization of skin wounds in the rat. Am Surg. 1986;52(12):659-662.
11. Knighton DR, Silver IA, Hunt TK. Regulation of wound-healing angiogenesis. Surgery. 1981:90(2):262-270.
12. Niinkoski J. Effect of oxygen supply on wound healing and formation of experimental granulation tissue. Acta Physiol Scand Suppl. 1969:334:1-72.
13. Hunt TK, Pai MP. The effect of varying ambient oxygen tensions on wound metabolism and collagen synthesis. Surg Gynecol Obstet. 1972:135(4):561-567.
14. Hsu RW, Hsu WH, Tai CL, Lee KF. Effect of hyperbaric oxygen therapy on patellar tendinopathy in a rabbit model. J Trauma. 2004;57(5):1060-1064.
15. Kindwall, Eric P; Whelan, Harry T (2004). Hyperbaric Medicine Practice, 2nd Edition Revised (Flagstaff, AZ: Best Publishing Company), 184-185.
16. Hohn DC, MacKay RD, Halliday B, Hunt TK. The effect of O2 Surg Forum. 1976:27(62):18-20.
17. Mader JT, Brown GL, Guckian JC, Reinarz JA. A mechanism for the amelioration by hyperbaric oxygen of experimental staphylococcal osteomyelitis in rabbits. J Infect Dis. 1980;142(6):915-922.
18. Dalton SJ, Whiting CV, Bailey JR, Mitchell DC, Tarlton JF. Mechanism of chronic skin ulceration linking lactate, transforming growth factor-beta, vascular endothelial growth factor, collagen remodeling, collagen stability, and defective angiogenesis. J Invest Dermatol. 2007;127(4):958-968.
19. World Union of Wound Healing Societies. Principles of best practice: Minimising pain at wound dressing-related procedures. A consensus document. London: MEP Ltd, 2004. Available from URL: http://www.wuwhs.org.
20. Silverstein P. Smoking and wound healing. Am J. Med., 1992;93 (Suppl 1A) :22S-24S.
21. Carrico TJ, Mehrhof Al, Cohen IK. Biology of wound healing. Surg Clinics of North America. 1984;64(94):721-733.
22. Cruse PJE, Foord R. A prospective study of 23,649 surgival wounds. Arch Surg. 1973;107:2006-210.