Periogenix

Periogenix
 
Periogenix
Intended to protect injured periodontal tissue by forming a temporary physical barrier to avoid further irritation.

OroScience® uses advanced science to develop ground breaking, easy to use products for oral wound healing, tissue regeneration, and oral disease management.

After years of research and 13 U.S. and foreign patients OroScience offers Periogenix™, the first stable oxygen foamed emulsion for the treatment of oral wounds.

Periogenix Graph
Application of Periogenix to injured tissues accelerates wound healing and improves clinical outcomes1,2
  • Accelerated healing of post-operative surgical wounds (partial thickness wounds and second degree burns; double blind, control, in vivo animal study p>.001)3
  • Wounds treated with Periogenix demonstrated an up-regulation of VEGF4, collagens I and III, and matrix metalloproteinase levels
Unlike occlusive wound dressings, the unique composition5 and emulsion structure of Periogenix allow for the exchange of oxygen and carbon dioxide into and out of injured tissues.6

This exchange of gas is essential to normal healing since the upper 0.25 - 0.40 mm of tissue derives its oxygen almost exclusively from the air and not the blood.7

Wound healing requires a variety of cells to increase their metabolic activity, resulting in a high oxygen demand.8,9 Oxygen at the wound site has been shown to promote wound healing by stimulating several processes, including;
  • Neovascularization10,11
  • Collagen production12,13,14
  • Epithelialization15
  • Phagocytosis (engulfing of microorganisms, cells, or debris by macrophages or neutrophils)16
  • Neutrophil-mediated oxidative microbial killing17
  • Degradation of necrotic wound tissue18
Lack of sufficient oxygen (hypoxia) has been associated with pain in the wound area,19 with the prevalence of hypoxia being more pronounced in patients who are smokers and diabetics. These populations demonstrate slower wound healing and increased risk of wound healing complications compared to healthy patients.20,21,22

Easy and comfortable use aids compliance
  • Included universal-fit disposable dental trays ensure comfortable consistent application
  • High concentration of oxygen produces significant emulsion expansion, ensuring good contact with the treatment area
  • Neutral taste and smooth texture
Available in the US only
For prescription Use Only in the United States. Federal Law restricts this device to sale by or on the order of a dentist, physician or properly licensed practitioner.

Kit Contents:
  • 30 ML (1 oz) Canister of Emulsion
  • 30 Disposable Dental Trays

* Epithelization was used as indicator of healing. Epithelization considered complete (healed) if no defect(s) were present; any defect(s) in the wound area indicated that healing was incomplete.

1. Accelerated Wound Healing in Animals; Davis SC, Cazzaniga AL, et al. Topical oxygen emulsion. Arch Dermatol. Oct 2007; 143(10):1256.

2. Clinical data on file.

3. Partial thickness wounds evaluated starting day 3 (p <0.001, days 4-7). 2nd degree burns evaluated starting day 7 (p <0.001, days 7-11, P<.01 day 12).

4. Vascular endothelial growth factor (VEGF).

5. Perfluorodecalin phase of Periogenix dissolves approx. 16x more O 2 and 3x more CO 2 than water (49 ml O 2 /100 ml and roughly 140 ml CO 2 /100 ml). Chemtech Volume 29, No. 10,7-12. (Table 1: Physical properties of water and some fluorocarbon liquids).

6. Data on file.

7. M. Stucker et. al. The cutaneous uptake of atmospheric oxygen contributes significantly to the oxygen supply of human dermis and epidermis. Journal of Physiology (2002), 538.3, pp. 985-994.

8. LaVan FB, Hunt TK, Oxygen and wound healing. Clin Plast Surg. 1990;17(3):463-470.

9. Niinlkoski J, Hunt TK, Dunphy JE. Oxygen supply in healing tissue. Am J Surg. 1972;123(3):247-252.

10. Meltzer T, Myers B. The effect of hyperbaric oxygen on the bursting strength and the rate of vascularization of skin wounds in the rat. Am Surg. 1986;52(12):659-662.

11. Knighton DR, Silver IA, Hunt TK. Regulation of wound-healing angiogenesis. Surgery. 1981:90(2):262-270.

12. Niinkoski J. Effect of oxygen supply on wound healing and formation of experimental granulation tissue. Acta Physiol Scand Suppl. 1969:334:1-72.

13. Hunt TK, Pai MP. The effect of varying ambient oxygen tensions on wound metabolism and collagen synthesis. Surg Gynecol Obstet. 1972:135(4):561-567.

14. Hsu RW, Hsu WH, Tai CL, Lee KF. Effect of hyperbaric oxygen therapy on patellar tendinopathy in a rabbit model. J Trauma. 2004;57(5):1060-1064.

15. Kindwall, Eric P; Whelan, Harry T (2004). Hyperbaric Medicine Practice, 2nd Edition Revised (Flagstaff, AZ: Best Publishing Company), 184-185.

16. Hohn DC, MacKay RD, Halliday B, Hunt TK. The effect of O2 Surg Forum. 1976:27(62):18-20.

17. Mader JT, Brown GL, Guckian JC, Reinarz JA. A mechanism for the amelioration by hyperbaric oxygen of experimental staphylococcal osteomyelitis in rabbits. J Infect Dis. 1980;142(6):915-922.

18. Dalton SJ, Whiting CV, Bailey JR, Mitchell DC, Tarlton JF. Mechanism of chronic skin ulceration linking lactate, transforming growth factor-beta, vascular endothelial growth factor, collagen remodeling, collagen stability, and defective angiogenesis. J Invest Dermatol. 2007;127(4):958-968.

19. World Union of Wound Healing Societies. Principles of best practice: Minimising pain at wound dressing-related procedures. A consensus document. London: MEP Ltd, 2004. Available from URL: http://www.wuwhs.org.

20. Silverstein P. Smoking and wound healing. Am J. Med., 1992;93 (Suppl 1A) :22S-24S.

21. Carrico TJ, Mehrhof Al, Cohen IK. Biology of wound healing. Surg Clinics of North America. 1984;64(94):721-733.

22. Cruse PJE, Foord R. A prospective study of 23,649 surgival wounds. Arch Surg. 1973;107:2006-210.


PGX001.A
Periogenix (1 Kit)  [ OR001-PGX-KIT-01 ]
Qty: Price:
1-5 $149.99
6-23 $145.00
24+ $140.00
Quantity:
  
Description
Periogenix Logo
Intended to protect injured periodontal tissue by forming a temporary physical barrier to avoid further irritation.
Periogenix - Connective Tissue Graft - Perio

Clinicians have seen excellent clinical results using Periogenix following a wide array of periodontal injuries including;

Non-surgical injuries:

  • Scale and root plane (SRP)
  • Crown placement
  • Laser based pocket decontamination and tissue augmentation

Surgical injuries:

  • Implant placement
  • Tooth extractions
  • Gingival grafts (both donor and recipient graft sites), flaps and gingivectomy
  • Crown lengthening
  • Bone grafts

Case Reports and Clinical Observations

Clinical case reports include:

  • Soft tissue grafting - Read PDF
  • Full mouth extraction followed by immediate placement of implants and dentures - Read PDF
  • Closure of a large palatal fistula - Read PDF
  • Esthetic crown lengthening - Read PDF
  • Minimally invasive therapy of early periodontitis - Read PDF

Clinicians have reported the following observations using Periogenix as a barrier:

  • Soft tissues appeared clinically to be in an advanced state of healing
  • Marked healing was noted at post-op visits
  • Patients used minimal analgesics throughout post-op management

Roles of O2 in Wound Healing

Unlike occlu sive wound dressings, the unique composition1 and emulsion structure of Periogenix allow for the exchange of oxygen and carbon dioxide into and out of injured tissues.2

Peer reviewed literature strongly supports the fact that gas exchange is essential to proper wound healing, with the upper 0.25 - 0.40 mm of tissue deriving its oxygen almost exclusively from the air and not the blood.3

Published literature demonstrates that oxygen at the wound site promotes wound healing by stimulating several critical wound healing processes, including:

  • Neovascularization (formation of new blood vessels)4,5
  • Collagen synthesis and epithelialization6,7,8
  • Neutrophil-mediated oxidative microbial killing9
  • Phagocytosis (engulfing of microorganisms, cells, or debris by macrophages or neutrophils)10
  • Degradation of necrotic wound tissues11

Wounds Lack Sufficient Oxygen

Peer reviewed literature has associated the lack of sufficient oxygen (hypoxia) with pain in the wound area, with the prevalence of hypoxia being more pronounced in patients who are smokers and diabetics.

These populations demonstrate slower wound healing and increased risk of wound healing complications compared to healthy patients.

  • Silverstein, P. Smoking and wound healing. Am. J. Med., 1992;93 (suppl 1A):22S-24S
  • Carrico TJ, Mehrhof Al, Cohen IK. Biology of wound healing. Surg Clinics of North America. 1984;64(94):721-733
  • Cruse PJE, Foord R. A prospective study of 23,649 surgical wounds. Arch Surg. 1973;107:2006-210
  • World Union of Wound Healing Societies. Principles of best practice: Minimising pain at wound dressing-related procedures. A consensus document. London: MEP Ltd, 2004. Available from URL: www.wuwhs.org.

1. Perfluorodecalin phase of Periogenix dissolves approx. 16x more O2 and 3x more CO2 than water (49 ml O2/100 ml and roughly 140 ml CO2/100 ml). Chemtech Volume 29, No. 10,7-12. (Table 1: Physical properties of water and some fluorocarbon liquids).
2. Data on file.
3. M. Stucker et. al. The cutaneous uptake of atmospheric oxygen contributes significantly to the oxygen supply of human dermis and epidermis. Journal of Physiology (2002), 538.3, pp. 985-994.
4. Meltzer T, Myers B. The effect of hyperbaric oxygen on the bursting strength and the rate of vascularization of skin wounds in the rat. Am Surg. 1986;52(12):659-662.
5. Knighton DR, Silver IA, Hunt TK. Regulation of wound-healing angiogenesis. Surgery. 1981:90(2):262-270.
6. Niinkoski J. Effect of oxygen supply on wound healing and formation of experimental granulation tissue. Acta Physiol Scand Suppl. 1969:334:1-72.
7. Hunt TK, Pai MP. The effect of varying ambient oxygen tensions on wound metabolism and collagen synthesis. Surg Gynecol Obstet. 1972:135(4):561-567.
8. Hsu RW, Hsu WH, Tai CL, Lee KF. Effect of hyperbaric oxygen therapy on patellar tendinopathy in a rabbit model. J Trauma. 2004;57(5):1060-1064.
9. Mader JT, Brown GL, Guckian JC, Reinarz JA. A mechanism for the amelioration by hyperbaric oxygen of experimental staphylococcal osteomyelitis in rabbits. J Infect Dis. 1980;142(6):915-922.
10. Hohn DC, MacKay RD, Halliday B, Hunt TK. The effect of O2 Surg Forum. 1976:27(62):18-20.
11. Dalton SJ, Whiting CV, Bailey JR, Mitchell DC, Tarlton JF. Mechanism of chronic skin ulceration linking lactate, transforming growth factor-beta, vascular endothelial growth factor, collagen remodeling, collagen stability, and defective angiogenesis. J Invest Dermatol. 2007;127(4):958-968.


MKT004.PGX.NL.A

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Testimonials

"At the 14 day post-op appointment, the sutures were removed, and the soft tissues appeared clinically to be in an advanced state of healing."

 Case Report: Connective Tissue Graft Bryan Pearson, DDS, MS
"Clinician was impressed with the rapid reduction of inflammation and swelling, pocket reduction, and restoration to a normal gingival contour."


 Case Report: Minimally Invasive Periodontitis Therapy Phil Mayers, DDS
"For demanding cases where optimal soft tissue healing is of paramount importance to the overall success, I feel that using Periogenix significantly enhances the final results." Case Report: Full Mouth Extraction and Immediate Implants Dr. Making Comment: J. Jerome Smith, DDS
"At 3 days post-op, healing appeared to be very good. At 10 days post-op, sutures were removed and soft tissue response was deemed excellent." Case Report: Surgical Esthetic Crown Lengthening Dr. Making Comment: J. Jerome Smith, DDS
"Examination indicated that the integrity of the incision was sound and healing continued to show remarkable results. The patient required minimal post-op analgesia and the fistula closure was a complete success." Case Report: Large Palatal Fistula Closure Dr. Making Comment: J. Jerome Smith, DDS